Rheumatoid arthritis often begins subtly, but when it affects the hands, it can disrupt your ability to perform even the simplest daily tasks. Whether you’re brushing your teeth, typing on a keyboard, or gripping a cup, persistent joint pain or stiffness may signal something more serious. Rheumatoid arthritis often begins subtly, but when it affects the hands, it can disrupt your ability to perform even the simplest daily tasks. Whether you’re brushing your teeth, typing on a keyboard, or gripping a cup, persistent joint pain or stiffness may signal something more serious.